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Interestingly, even in studies where beta-3 receptors were absent, some metabolic effects persisted with acute dosing, suggesting secondary mechanisms may exist

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It has also been associated with psychogeriatric dis-ease, depression, high neurotoxin activity, and a decrease in intellectual function such as episodic and visuospatial memory, attention, and abstract reasoning (20).Reynolds and colleagues found that 17 out of 24 hospitalized patients (71%) presenting severe folic acid deficiency were diagnosed with depression (46)

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