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Patients should be counseled to monitor urine color (pale yellow indicating adequate hydration) and to increase fluid intake during exercise or hot weather
10.1111/j.1460-9568.2004.03306.x Eur
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& Tillmann, B
These findings suggest that liraglutide specifically reduces bone resorption without influencing bone formation.368 Since GLP-1R is expressed in thyroid C cells and GLP-1 directly stimulates the secretion of calcitonin, which is a potent inhibitor of bone resorption in osteoclasts, GLP-1 may contribute to the nutrient-mediated reduction in bone resorption.369,370 Genetic disruption of GLP-1R signaling leads to cortical osteopenia and heightened bone fragility, primarily caused by increased bone resorption by osteoclasts
For context, in a previous Phase 3 trial of Zepbound, the highest-dose group saw a dropout rate of only 6.2% due to adverse events
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