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Peptone-triggered secretion of GLP-1 from murine primary colonic cultures is also abolished in the presence of CaSR antagonists and removal of extracellular calcium, though whether this effect represents the sensing of individual amino acids generated by initial protein breakdown, or the ability of small peptides to bind to the CaSR is unclear (132)

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doi:10.3389/fendo.2021.576412 96

Consider adding electrolytes to your water, especially in the first few weeks

(Is it effective?) The honest answer is: it depends on the goal