In the coupling reaction, the iodinated tyrosine residues are combined by TPO to make triiodothyronine (T3) and tetraiodothyronine (T4), where MIT and DIT join to form T3, and two DIT molecules form T4
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[5, 6] It is considered the main redox buffer in human cells owing to its large amount of reducing equivalents, [7] and is an important enzyme cofactor that serves as a neuromodulator in the central nervous system
Diagnostic Use: Helps differentiate benzodiazepine intoxication from other causes of CNS depression