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The receptor was pivotal to the ability to create long-lasting GLP-1 drugs for diabetes and obesity

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114 Moreover, the loss of functional microglial autophagy is deleterious as it exacerbates tau pathology and spreading in PS19 tau transgenic mice, 152 as well as contributes to elevated release of pro-inflammatory cytokines and NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation in Becn1 +/ APP/PS1 mice