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The basement membrane covers the adventitial surface of ECs and extends around capillaries but separates postcapillaries at venules
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The control of HLA-I expression is also dependent on transcription factors including NF-B and NLRC5, as well as epigenetic processes, the disruption of which would have a major impact on antigen presentation (82)
In other words, in addition to inhibiting the expression of p-STAT3, GHK-Cu likely targets other pathways that inhibit the expression of inflammatory factors
Clinical Insight: This synergy protects cells under stress
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