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For the dichotomous variables, we counted the number of cases, using the average RR to estimate the risk ratio.The WMD and RR with 95% CI were calculated for the continuous and dichotomous outcomes respectively, to represent the pooled effects and safety conditions of semaglutide on outcomes of interest

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This is a primary factor contributing to the development of drug resistance

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Serious Adverse Events Both medications carry the same class-wide warnings: risk of pancreatitis, gallbladder disease (particularly at higher rates of weight loss), and a theoretical risk of medullary thyroid carcinoma (MTC) based on rodent studies