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This is why looking for liposomal or stabilized forms is often recommended
178,179 Some evidence also suggests earlier initiation of hormone replacement therapy (within five years of menopause) may be preferred over later initiation (between five and 10 years after menopause) in terms of cognitive function
Singh, Namita & Kushwaha, Poonam & Ahmad, Usama & Abdullah, Mohammad
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Alzheimers Res Ther 2014;6:37-45
Frohman LA et al
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