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No effect of 600 grams fruit and vegetables per day on oxidative DNA damage and repair in healthy nonsmokers
6 Key Takeaway
2024;7:e2416775
Epitalons appeal lies in its unusually broad mechanistic reach: it can activate telomerase and support telomere maintenance in human cells [12,13,14, 15], modulate gene expression epigenetically by influencing chromatin accessibility and promoter interactions [4], enhance tissue repair in disease contexts such as diabetic retinopathy by reducing oxidative stress and EMT while improving wound healing in retinal cells [16], bolster redox homeostasis by upregulating endogenous antioxidant defenses and lowering DNA-damage markers [1], rebalance immune tone via IL-2 upregulation [17] and shifts in CD4+/CD8+ profiles [18], and even reset circadian biology by tuning core clock genes and melatonin dynamics [19, 20]
Endothelial dysfunction in cirrhosis: role of inflammation and oxidative stress
The sweet spot is 500 mg daily, taken via oral supplementation
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