Eur J Endocrinol 162(1):161167 Kachouei A, Rezvanian H, Amini M, Aminorroaya A, Moradi E (2018) The effect of levothyroxine and selenium versus levothyroxine alone on reducing the level of anti-thyroid peroxidase antibody in autoimmune hypothyroidism patients
Both use large datasets
NICE guidance on obesity management (CG189) emphasises evidence-based interventions including dietary modification, increased physical activity, behavioural therapy, andwhere appropriatepharmacotherapy with licensed medications such as orlistat or semaglutide (NICE TA875)
The nausea typically signals that the medication is working on appetite pathways
Always consult your healthcare provider, especially if you're on medication or have specific health conditions
Persistent vomiting or diarrhoea can lead to dehydration, which in turn may increase the risk of acute kidney injury a class-relevant concern also noted in the Summary of Product Characteristics (SmPC) for approved GLP-1 receptor agonists such as semaglutide