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High levels of homocysteine, with the slowing of GPx1 blood vessel activity, promote a higher concentration of intracellular peroxides that enhances oxidative stress and causes damage to endothelial cells in the pathogenesis of atherogenesis

Shuja N, Bajwa UM, Iqbal S, et al Assessment of circulating biochemical markers and antioxidative status in patients suffering from melasma Pak J Med Health Sci

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Some deep-chested large breeds are also prone to bloat, a life-threatening condition in which the stomach expands and twists when they swallow excess gas

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