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For oral squamous cell carcinoma (OSCC), QUE inhibited cholesterol metabolism by inhibiting the AGR2/AKT/SREBP2 signaling pathway, enhancing CIS sensitivity to CIS-resistant CAL-27 cells (60)

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Its GLP-1/GIP molecule (called MariTide) is in Phase 3, and Amgen is constructing two fill/finish plants in Holly Springs (initially $550M, then $1B added for expansion) ( [61] )

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