Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
Supplements deliver a concentrated, high-potency dose of B vitamins that can sidestep some of these absorption roadblocks
Results from a 16-week study suggest that the CJC-1295 analog may influence the growth hormone and IGF-1 levels
(1) More specifically, AOD 9604 is considered the lipolytic fragment of GH as different parts of the GH molecule appease to have different potentials

Tesamorelin Specifications Molecular Formula: C 221 H 366 N 72 O 67 S Molecular Weight: 5136 g/mol Sequence: trans-hexenoyl-acid-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-AsnSer-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-LeuGln-Asp-Ile-Met-Ser-Arg-GlnGln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu CJC-1295 (Mod GRF 1-29) Specifications Molecular Formula: C 152 H 252 N 44 O 42 Molecular Weight: 3367.954 g/mol Sequence: YDADAIFTQSYRKVLAQLSARKL LQDILSR-NH2 Ipamorelin Specifications Molecular Formula: C 38 H 49 N 9 O 5 Molecular Weight: 711.868 g/mol Sequence: Aib-His-D-2Nal-D-Phe-Lys Tesamorelin & CJC-1295 (Mod GRF 1-29) & Ipamorelin Research Tesamorelin & CJC-1295 (Mod GRF 1-29) & Ipamorelin and Structural Modifications The Tesamorelin & Mod GRF & Ipamorelin blend appears to act primarily via the GHRH receptors in the central nervous system, particularly the pituitary cells (somatotrophs) found in the anterior part of the gland

The gap between what we know and what we'd like to know about 5-Amino-1MQ's long-term profile will narrow as more trials complete