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Cleto AS, Schirlo JM, Beltrame M, et al

In adults with overweight or obesity (without diabetes) the semaglutide 2.4 mg dose produced an average weight reduction of about 15% of baseline body weight over ~68 weeks in the STEP 1 trial, a result that surprised many clinicians because it brought pharmacologic outcomes into a range previously associated with surgical interventions

While GLP-1 receptor agonists can help promote fat loss and improve metabolic health, they can also lead to unintended muscle loss if not paired with strength training

Diet Approaches to Increase GLP-1 There is no one-size-fits-all diet, but you have options

How difficult it is to change dietary behaviour experience of older people with sarcopenic obesity: a qualitative study

Phase Therapeutic range Weeks 13-16 Weekly Dose 9 mg Notes Skip to 9 mg or hold at 6 mg by tolerance