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Nausea, vomiting, and diarrhea were typically the most common gastrointestinal adverse events, occurring in up to 48.4%, 23.2%, and 23.1% of participants, respectively, with events occurring predominantly during dose escalation and decreasing over time [10, 37, 43, 45,46,47]
In a mouse study, green coffee bean extract, a rich source of chlorogenic acid, significantly reduced visceral fat accumulation and improved insulin sensitivity, effects that may have been due to suppression of genes associated with fat deposition and inflammation (Song 2014)
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Cai Q, Zakaria HM, Simone A, Sheng Z-H
This matters because a compound that weakly hits three targets would be less useful than one that strongly hits two
However, there are presently limited interventional data regarding the additive benefits and optimal approaches to using these therapies in combination
