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Have a demonstrated medical need for treatment
That is the honest read of the 2025 tirzepatide vs semaglutide evidence, and it is why EASO 2025 guidelines treat both drugs as first-line with tirzepatide favored for obesity without CV disease
New or worsening heartburn that does not respond to over-the-counter antacids, as this may indicate gastroesophageal reflux disease requiring treatment
The observed association between ADHD and obesity (Cortese et al., 2016) invites speculation that medications impacting metabolic pathways might also influence neural mechanisms relevant to ADHD
For antihypertensive drugs like ACE inhibitors (lisinopril, ramipril), only minor changes in drug levels have been noted, which are generally not clinically significant
It notes that research settings can track drug levels using mass spectrometry or isotope labelling, but says those methods are not available in typical outpatient care
