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doi: 10.1681/ASN.2006010029 26 CuginiPMuranoGLuciaPLetiziaCScavoDHalbergFet al

Stop taking blood thinners 1-2 weeks before

The most common typically strongest in the first 48 weeks as the body adapts include: Nausea (most common, usually dose-dependent) Diarrhoea or constipation Fatigue , especially during dose escalations Mild headache Reflux and acid reflux Loss of appetite (this is the therapeutic effect, not a side effect, but it can be uncomfortable) Less common but more serious effects warranting immediate physician review include pancreatitis, gallbladder disease, and kidney issues, particularly in patients with pre-existing conditions

Currently, Medicare is legally prohibited from covering drugs that are indicated for weight loss, including Wegovy and Zepbound

A history of these conditions does not automatically end the conversation, but it may change the calculus, prompt additional evaluation, or lead a clinician toward a different approach

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