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The ingredients in Activate, particularly the combination of hibiscus and lemon verbena polyphenols, have been shown in clinical studies to modestly increase GLP-1 levels (12-22% above baseline)

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Researchers have linked Breast Colorectal Endometrial Esophageal Gallbladder Kidney Liver Meningioma (a type of brain tumor) Multiple myeloma (a type of bone marrow cancer) Ovarian Pancreatic Stomach (gastric) Thyroid Between December 2014 and June 2025, 38% of study participants received a GLP-1 prescription, and the remaining 62% received diet and exercise counseling