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Endogenous cysteine synthesis is predominantly achieved through the conversion of homocysteine (Hcy) and through GSH and protein degradation

SAMe is then utilized as a donor of its methyl group to methylate many substrates to fulfill diverse biological functions

Results Preparation of the D-CuP The dimeric peptide D-P was synthesized through the covalent conjugation of two glycyl-l-histidyl-l-lysine (GHK) tripeptide moieties utilizing lysine as the bridging molecule (Fig