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Oxidative deamination of methylamine by semicarbazide-sensitive amine oxidase leads to cytotoxic damage in endothelial cells
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Unlike some alternatives, it does not increase appetite, cortisol, or prolactin
Oral Dosing Runs Higher Injectable: 200 to 500mcg per dose Oral: 500 to 1,000mcg per dose, once or twice daily, taken on an empty stomach Higher oral doses are used to make up for the fact that the gut absorbs the compound poorly compared to injections
One study found that GHK-Cu at very low concentrations could promote the growth of certain cell types involved in wound repair
MECHANISM CATEGORIES SAFETY Side effects GI: nausea, vomiting (titration-dependent) Injection-site reactions Hypoglycemia risk when combined with insulin Known interactions Insulin additive hypoglycemia risk Contraindications History of MTC or MEN2 (theoretical class effect) REGULATORY STATUS FDA Not yet FDA-approved as of 2026-05
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