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This mechanism may provide pain relief without the tolerance and dependence issues associated with direct opioid receptor agonists

Healthcare providers typically start patients on a lower dose and gradually increase it based on individual response and tolerance

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The traditional pathways have always been through your health plan or your employer, and those continue to remain obviously very important, but we know consumer behavior is changing, and people are engaging in their health and making healthcare decisions in lots of places," Bliss said

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