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PMID: 41084392 Phytomedicine Sarmentosin promotes USP17 and regulates Nrf2-mediated mitophagy and cellular oxidative stress to alleviate APAP-induced acute liver failure

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Found in every cell of the body, it is particularly abundant in the liver, where it plays a central role in detoxification

As both H 2 O 2 and BCNU exposure led to excessive cellular GSSG accumulation, their impact on intracellular protein-GSSG adduct formation (protein S -glutathionylation) was subsequently examined in HepG2 cells by western blot analysis using a monoclonal GSSG antibody that specifically binds to GSSG-modified proteins

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Notably, the treatment preferentially preserved the inner tibial cartilage zone and was associated with a trend toward reduced osteophyte formation [139]