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One of the most common concerns patients experience is digestive discomfort, especially constipation

Some studies indicate that aligning eating windows with circadian rhythms could affect hormone responses, but this area requires further investigation before specific recommendations can be made

BMJ Disease Reviews Finally, a systematic review and meta-analysis in JAMA Neurology (2025) pooling randomized cardiometabolic trials found no overall cognitive/dementia benefit across all cardioprotective diabetes drugs , but GLP-1 RAs stood out with a statistically significant reduction in incident dementia in subgroup analysesimportant but still Can GLP-1 Drugs Help Prevent Dementia

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Kidney problems Severe vomiting or diarrhea can lead to dehydration