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Finally, the important but less common outcome of nonfatal stroke was reduced with GLP-1RA, particularly in the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) 6 trial (semaglutide once weekly injection) and Researching Cardiovascular Events With a Weekly Incretin in Diabetes (REWIND
When losing weight, our bodies naturally adapt
On top of that, one of the biggest complaints about GLP-1s, when taken according to the standard doses approved by the FDA is that they cause side effects such as nausea, diarrhea and fatigue
There was this realization that, while obesity is not something that is a persons fault or a value judgement about their willpower or anything else, obesity has significant health risks associated with it, and we should treat it like we do other chronic illnesses, he adds
no such reduction was seen with placebo
Ideal candidates might include those who: Have documented binge eating episodes causing significant distress Meet BMI criteria for weight management medications Have not responded adequately to psychological interventions (such as cognitive behavioural therapy) Do not have contraindications to GLP-1 therapy Understand the off-label nature of this indication UK SmPCs for GLP-1 medications note findings of thyroid C-cell tumours in rodent studies, though the relevance to humans remains uncertain
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