when were glp 1 agonists discovered Reflections on the discovery GLP-1 as a satiety hormone: Implications for obesity therapy and future directions GLP-1 Drug Discovery Timeline: From

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Semaglutide had been approved for both diabetes and obesity treatment, while tirzepatide was only approved for obesity in November of 2023 ( Regarding the time of onset, our study showed that the median time to onset of the overall GLP-1 RA AEs was 31 days (IQR = 7145.4 days)

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Other contraindications include allergies to the compounds, severe renal and hepatic diseases, and a history of skin cancer