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Acknowledgements We thank the staff of the Animal Magnetic Resonance Research Center of the First Affiliated Hospital of Jinan University for performing the animal MRI scans

For the DIA-PASEF method, we used the Bruker standard short gradient method (m/z range: 4751000 Da, 1/K0 range: 0.851.27 Vs cm 2 , diaPASEF windows: 21 25 Da)

Autonomic complaints in patients with restless legs syndrome

Toxicology workup as indicated (e.g., salicylate level, urine toxicology screen including cocaine and methamphetamine)

Glutathione production unfortunately decreases with age

In other species and contexts, L-carnitine has been discussed in relation to valproic acidassociated toxicity (Gziut T, 2025), which is a reminder that nutrient doesnt automatically mean neutral in complex medical cases