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Appetite usually increases, and the feeling of fullness after meals may decrease

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Briefly, using the genome of E

While the gastrointestinal effects (nausea, diarrhea, vomiting) are similar to other GLP-1 medications like Wegovy and Mounjaro, retatrutide has one unique finding: dysesthesia (abnormal touch sensations) in 20.9% of patients at the 12mg dose in TRIUMPH-4, and 12.5% at 12mg in the larger TRIUMPH-1 trial

Symptoms closely related to anxiety, such as irritability, agitation, and restlessness, are often reported simultaneously, says Psych Central

Other common systemic side effects include constipation, diarrhea, headache, and fatigue