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We and others have shown that circulating leptin levels are reduced in chronic stress animal models of depression [15,16,17], whereas systemic and intracerebroventricular injections of leptin produce antidepressant-like behavioral effects [15, 18,19,20]
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It has shown activity at very low doses (nanogram to microgram per kilogram) without demonstrable toxicity in animal studies [11]
Oxidative phosphorylation as an emerging target in cancer therapy
doi: 10.1016/j.foodqual.2025.105507 27 DixonJ
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