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NICE has not yet issued guidance on either agent, as appraisal processes are typically initiated only after regulatory approval, although scoping can occur earlier
The golden dose is informal language thats circulated on social media and forums to describe a specific dose level at which weight loss feels most consistent and side effects most manageable
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JAMA Network Open (August 12, 2025) reports higher risk of nonarteritic anterior ischemic optic neuropathy across ~1.5M patients, and a separate analysis in ~185k found a modest uptick in diabetic retinopathywhile sight-threatening events were less frequent on GLP-1s
However, despite significant weight loss, liraglutide-treated animals displayed increased bone mass, trabecular number, and cortical thickness in the appendicular and axial skeletons, with marked improvement in bone formation parameters [55,56,57]
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