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Secondly, it is now known that DPP-4 also cleaves several other peptides, some of which have direct actions on the cardiac and vascular cells

Accordingly, in vitro and ex vivo studies have shown that exposure to saxagliptin (135, 136) but not sitagliptin (136), results in altered cardiac electrophysiology and is associated with impaired cardiomyocyte contractility

GLP-1s mimic a hormone produced in the gut to suppress a persons appetite and regulate blood sugar

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GLP-1s mimic a hormone important to regulating hunger and metabolism