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N Engl J Med 316:971977

Compounding pharmacies have applied this research pragmatically by including B12 in their tirzepatide formulations

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19 We speculate that patients with clEDS may be more prone to have structural defects along the walls of the gastrointestinal tract, which can predispose to diffuse diverticulosis, diverticulitis, and resulting bowel perforation as well as to perforation during invasive procedures and spontaneous perforation

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