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Las potenciales explicaciones incluyen diferencias en el tipo de pacientes incluidos, la adherencia al tratamiento del estudio, el tamao muestral, la duracin de la exposicin al frmaco y la activacin del receptor GLP1 con una mayor reduccin de HbA1c con anlogos basados en GLP1 humano de accin ms prolongada que con algunos anlogos de exendina 4 de accin corta
Anecdotal reports from some patients have suggested changes in libido during treatment with GLP-1 receptor agonists, though these observations have not been systematically studied or confirmed in controlled research
Furthermore, the risk of hypoglycaemiaa major challenge when using insulinis reportedly lower with GLP-1RAs, given their glucose-dependent mechanism of modulating insulin release and glucagon suppression [25]
Turner et al., 2015
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