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This can result in the formation of dark spots and skin irregularities, and the skin loses its healthy glow

These factors can include 4 : DAO deficiency : Reduced levels of the diamine oxidase enzyme, often due to genetics, gut inflammation, or medication use

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Cancer cells reprogram iron handling to sustain rapid proliferation, leading to expansion of the intracellular labile iron pool (LIP), composed largely of redox-active ferrous iron (Fe 2+ ) (67, 68)

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