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glp-1 versus glp-2

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A separate In a large cohort of patients with type 2 diabetes, researchers found that GLP-1 use was not associated with a higher incidence of NAION but was linked to another eye condition: diabetic retinopathy

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When the C-tails were swapped between species, there was no significant impact on G protein-mediated signaling, but arrestin recruitment to the human receptor was impaired when its tail was substituted with that of either the rat or the mouse receptor

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Muller TD, Finan B, Bloom SR, D'Alessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, Holst JJ, Langhans W, Meier JJ, Nauck MA, Perez-Tilve D, Pocai A, Reimann F, Sandoval DA, Schwartz TW, Seeley RJ, Stemmer K, Tang-Christensen M, Woods SC, DiMarchi RD, and Tschop MH

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