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It is worth emphasizing that there is a trade-off between precision and stability among these strategies: direct inhibition of pathways acts quickly but may disrupt physiological inflammatory regulation, while indirect regulation, though slower to take effect, aligns more closely with the bodys self-regulatory mechanisms
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The STEP 4 extension trial showed that participants who discontinued semaglutide regained approximately two-thirds of their lost weight within one year [10]
Yuan XH, Fan YY, Yang CR, et al
It showed a 2*-fold increase in GLP-1 secretion And a 67*% reduction in ghrelin , the hunger hormone Together, these effects help the body better regulate hunger and reduce the urge to snack not by force, but through restored internal balance
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