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Retatrutide's Phase 2a in MASH/MASLD (Sanyal et al., Nat Med 2024) reported approximately 86% relative reduction in liver fat content at 12 mg/week the strongest hepatic-fat data among the incretin class
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More substrate available to that enzyme means more nitric oxide released, which relaxes vascular smooth muscle and lowers resistance to flow
Retrospective case series of paediatric patients referred to national poisons centres also report a lower rate of liver injury and hepatotoxicity in children compared with adults following single acute overdose [52,53,54,55]
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