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Interestingly, whole-body, or CNS-specific, GLP-1R knockout in a mouse did not result in sizable change in body weight, fat mass or hyperphagia

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Macronutrient Distribution Beyond total calories, macronutrient ratios influence body composition outcomes

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Their actions include reversing the Warburg effect, restoring mitochondrial oxidative metabolism, regulating lipid and amino acid homeostasis, and enhancing the arginine-NO pathway

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