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Reducing glutathione production in lymphoma cells, either through pharmacological inhibition of glutamate cysteine ligase (GCL), the enzyme catalyzing the rate-limiting step in glutathione biosynthesis, or via knockdown of GCLC , the GCL catalytic subunit, sharply decreased cell growth in 3D gels and xenografts

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GHK-Cu is not currently approved by the Therapeutic Goods Administration (TGA) for therapeutic use in Australia

Finally, we have validated ionomycin (1 M) as a positive control of eryptosis under these conditions