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Cu(II) is held in a square-planar coordination sphere by the N-terminal amine, the deprotonated glycyl amide nitrogen and the histidine imidazole, at a stability constant (log K approximately 16.4) close to that of the copper transport site on human serum albumin
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2019 Aug 29;381(9):841-51.
It delivers a more potent GH pulse than a GHRH analog like Sermorelin but without the significant cortisol and prolactin spikes associated with older GHRPs like GHRP-2 or the formidable Hexarelin
This process may further activate the NLRP3 inflammasome, resulting in excessive release of inflammatory cytokines such as IL-1 and amplifying systemic inflammation (97)
Raybould, H
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