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The 5-on/2-off rhythm respects this pulsatile biology longer or more frequent dosing increases receptor desensitization without meaningful gain

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A., Len-Cabrera, S., et al

doi: 10.1016/j.radonc.2020.03.038 365 ZhouH.ZhaoC.ShaoR.XuY.ZhaoW

Chem Soc Rev 50:45414563 Du C, Xu Y, Wei G (2025) Recent advances in biomolecule-engineered metal-organic frameworks (Bio-MOFs): from design, bioengineering, and structural/functional regulation to biocatalytic applications