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When comparing Ozempic vs Trulicity , both medications belong to the GLP-1 receptor agonist class and effectively manage type 2 diabetes, but Ozempic (semaglutide) generally provides greater A1C reduction and more significant weight loss compared to Trulicity (dulaglutide)

Ozempic is the original brand name of semaglutide used mainly for type 2 diabetes, while higher-dose semaglutide is also used for obesity and weight loss