Considering that this latter neuronal population is involved in sleep-cycle regulation, it is tempting to speculate whether the inhibitory action of OX-A on REM sleep could be mediated, at least in part, by decreasing GHRH mRNA expression in the PVH
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In experimental models, it may be included as a reference peptide when studying stress-response pathways, circadian-adjacent biology, and downstream molecular readouts linked to brainbody communication
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Energy dips most noticeably 12 to 36 hours post-injection, then gradually normalizes