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Recently, the FDA approved omaveloxolone, a potent activator of Nrf2 signaling, as the first therapeutic agent for FRDA (392), marking a significant step toward targeting redox imbalance and ferroptosis in this disease
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Therefore, we treated in vitro activated B6 FoB with various mitochondrial inhibitors and the Gclc inhibitor BSO and measured total immunoglobulins from the supernatants
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