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Biochemical and biophysical research communications , 280 (1), 132138
Inflammation and SASP Investigations: Allows researchers to study the senescence-associated secretory phenotype (SASP) and its effects on tissue inflammation
Whether this reflects a shift from GHD1 to GDH2 isoform [28] is not known but, if so, this pushing effect of reduced pH effect could be additive with the above pulling effect of a reduced TCA pool (Figure 2)
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Notably, similar inhibitions were observed both with the wild type enzyme and its cysteine mutants, suggesting that thiol conjugation is dispensable for GST inactivation by auronofin in contrast to other described targets 103
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