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[14] The evidence base consists primarily of secondary analyses and observational data rather than randomised controlled trials specifically designed to assess antidepressant effects

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This can be interpreted as a surrogate for the compounds on-target activity (Fig

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GLP-1 agonists were on the market in 2005 with exenatide

Growth hormone works best when insulin levels are low, as insulin directly antagonizes HGH signaling at the receptor level