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This precision-wellness approach can help guide comprehensive, evidence-informed decision-making about symptom management and neuroprotection

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Data availability All data from this study are presented in the published article and the supplementary material

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Methods Ethical approval All animal experiments reported herein were performed following the guidelines and were approved by Peking University Institutional Animal Care and Use Committee (LA2021316)

In both cohorts, the largest proportion of significant metabolite ratios was associated with asthma exacerbations, whereas a relatively small proportion of metabolite ratios was associated with lung function and log(IgE)