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Moreover, our study revealed that serum-derived Exos from SAP model mice alleviate or prevent SAP-associated lung injury by targeting pulmonary microvascular endothelial barriers via the upregulation of the integrins ITGAM and ITGB2
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This extension not only increased the molecular weight (from 7.6 kDa to 9.1 kDa), but also reduced the affinity for IGF binding proteins (IGFBPs) through steric hindrance effect
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