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Science 286 , 13211326 (1999)

Molecular Formula: C400H625N111O115S9 Amino Acid Sequence: MFPAMPLSSLFVNGPRT LCGAELVDALQFV CGDRGFYFNKPTGYGSSSRRAPQT GIVDECCFRSCDLRRLEMYCAP LKPAKSA View the HPLC Certificate here

A 2023 preclinical study in Arthritis Research & Therapy demonstrated that TB-500 administration increased Treg populations in synovial fluid by 34% within six weeks, correlating with reduced joint swelling scores

10.3390/antiox10050642 6 AwadF.AssrawiE.LouvrierC.JumeauC.GiurgeaI.AmselemS.et al (2018)

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12 Moreover, lipotoxicity, endotoxin translocation, and chronic low-grade inflammation activate Kupffer cells (KCs) and polarize immune cell populations, 13 contributing to a persistent pro-inflammatory hepatic microenvironment