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A variety of ferroptosis inducers can influence glutathione peroxidase directly or indirectly via diverse pathways, leading to decreased antioxidant capacity, accumulated cellular lipid peroxides, and finally inducing ferroptosis
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In addition to safeguarding the cardiovascular system, GLP-1RA also exerts a protective effect on the kidney
Three amino acid-altering GIP receptor variants (R190Q, E288G, and E354Q) are all associated with lower bone mineral density, and in postmenopausal women followed for 10 years, who were homozygous carriers of the E354Q variant, showed a higher risk of non-vertebral fractures (99, 101)
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This combination of effects creates an environment conducive to weight loss, as people naturally eat less while their bodies maintain lower insulin levels
