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The ratio [GSH]/[GSSG] is thought to be around 100 for cells that are not under oxidative stress [41], and [GSH]/[GSSG] = 107.5 in our model cell

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KPV contributes direct intracellular anti-inflammatory effects through NF-B pathway inhibition, distinguishing it from receptor-mediated anti-inflammatory approaches

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This paradigm shift further strengthens the transition toward precision obesity medicine, driven by phenotype, risk stratification, and measurable clinical outcomes